Calcium antagonists in exercise-induced asthma.
نویسندگان
چکیده
منابع مشابه
Calcium antagonists in exercise-induced asthma.
Ten patients with exercise-induced asthma participated in a single-blind trial comparing the protective effects of inhaled verapamil (estimated dose 3 mg) and sodium cromoglycate (estimated dose 12 mg). Saline was used as control. Effects were assessed from the mean maximal percentage fall in forced expiratory volume in one second (FEV1) after running on a treadmill for eight minutes. There was...
متن کاملEffect of calcium antagonists in experimental asthma.
Verapamil was found to be an effective inhibitor of isometric tension in in vitro, experimental anaphylaxis in guinea pig trachealis smooth muscle. The mean IC50 for protection studies was 2 X 10(-4) M; the drug was also effective as a bronchoreversal agent. The inhibitory effect of verapamil upon the initial rate of isometric muscle tension suggests an action beyond simple calcium channel inhi...
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In eight extrinsic asthmatic subjects (age range 16-38 years) there was a significant reduction (p less than 0.01) in the severity of bronchoconstriction after a treadmill exercise test performed 30 minutes after nifedipine 20 mg sublingually. The maximum fall in peak expiratory flow after exercise was 36.0 +/- SEM 5.3% compared with a maximum fall of 56.5 +/- 4.1% after matched placebo capsule...
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The article in this issue of RESPIRATORY CARE by Burnett et al1 reports that 34 of 80 college athletes had exerciseinduced bronchoconstriction (EIB), most in the absence of symptoms. The authors further suggest that these athletes are at risk and that the identification of those with EIB may prevent morbidity and mortality. The implication is that the presence of EIB is evidence for asthma. But...
متن کاملSpecificity of exercise in exercise-induced asthma.
Ventilatory function after three types of exercise-running, cycling, and swimming-was studied in 10 control subjects and 40 asthmatic patients. All performed eight minutes of submaximal aerobic exercise during each of the programmes, which were conducted in a randomly selected order. Biotelemetric monitoring of heart rates was used to equate the intensity of the exertion undertaken during the t...
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ژورنال
عنوان ژورنال: BMJ
سال: 1981
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.282.6268.932